Prof. Dr. Dorothea von Haebler

Language

English

Homepage URL

http://dx.doi.org/10.1016/s2215-0366(26)00240-3

Contributors

• Christiane Montag (Author)
• Anna-Lena Bröcker (Author)
• Samuel Bayer (Author)
• Katrin Becker (Author)
• Gianna Bertram (Author)
• Marielle Büttner (Author)
• Jakob Funcke (Author)
• Imke Grimm (Author)
• Sandra-Anna Just (Author)
• Jasmina Hadzibegovic (Author)
• Eva Maaßen (Author)
• Ivan Nenchev (Author)
• Frauke Stuke (Author)
• Felix Bermpohl (Author)
• Andreas Heinz (Author)
• Günter Lempa (Author)
• Dorothea von Haebler (Author)

Added

2026-09-12

Last modified

2026-09-12

Language

German

Subtitle

Psychodynamische Diagnostik und Fallformulierung

Homepage URL

http://dx.doi.org/10.1024/86464-000

Contributors

• Michael Stasch (Author)
• Johannes C. Ehrenthal (Author)
• Tilman Grande (Author)
• Paul L. Janssen (Author)
• Claudia Oberbracht (Author)
• Gerd Rudolf (Author)
• Dorothea von Haebler (Author)

Description

<jats:p>&lt;p&gt;In diesem Buch bündeln erfahrene OPD-Trainer*innen, Gutachter*innen und Antragssteller*innen aus der Praxis ihre Expertise in der Richtlinien-Psychotherapie. Anhand zahlreicher Beispiele wird der Prozess der OPD-gestützten Urteilsbildung und Befundformulierung nachvollziehbar dargestellt – von der ersten Kontaktaufnahme über die Strukturierung des klinischen Materials bis hin zu psychodynamischen Reflexionen und der konkreten Formulierung des Berichts für den Antrag.&lt;/p&gt; &lt;p&gt;Schritt für Schritt, eng am OPD-Manual orientiert und praxisnah aufbereitet, erleichtert das Buch die Umsetzung der Operationalisierten Psychodynamischen Diagnostik im klinischen Alltag. Die verschiedenen Settingvarianten psychodynamischer Psychotherapie (Einzel, Gruppe und Einbezug der Bezugspersonen) werden ebenso wie unterschiedliche klinische Aspekte – etwa Behandlungsplanung bei neurotischen, strukturell beeinträchtigten, psychotischen oder traumatisierten Patient*innen – exemplarisch dargestellt.&lt;/p&gt; &lt;p&gt;Das vorangegangene Buch („OPD-2 in der Psychotherapie Antragsstellung“) wurde gründlich überarbeitet, um die Neuerungen und Erweiterungen von OPD-3 zu integrieren und an die aktuell gültige Psychotherapierichtlinie anzupassen. Ein unverzichtbares Werkzeug für alle, die OPD-3 fundiert in der Antragstellung einsetzen möchten.&lt;/p&gt;</jats:p>

Added

2026-09-12

Last modified

2026-09-12

Subtitle

Eine Chance im Maßregelvollzug

Homepage URL

https://doi.org/10.1007/s11757-026-00928-4

Contributors

• Dorothea von Haebler (Author)

Added

2026-03-16

Last modified

2026-05-04

Language

German

Homepage URL

http://dx.doi.org/10.1055/a-2777-2408

Contributors

• Robert Scheele (Author)
• Dorothea von Haebler (Author)
• Christiane Montag (Author)
• Moritz Bruno Petzold (Author)

Description

<jats:title>Zusammenfassung</jats:title> <jats:p>Die Studie untersucht die mediale Darstellung von Schizophrenie und Psychose in der Frankfurter Allgemeinen Zeitung in den Jahren 2004, 2013 und 2023. Im Fokus steht die metaphorische Nutzung der Begriffe, ihre Kontextualisierung mit Straftaten sowie die Darstellung von Behandlungsmöglichkeiten.</jats:p> <jats:p>Grundlage ist systematische Volltextanalyse von 709 Artikeln, die auf vordefinierten inhaltlichen Kategorien basiert.</jats:p> <jats:p>Die Ergebnisse zeigen einen Rückgang metaphorischer Verwendungen von 44,9% im Jahr 2004 auf 30,8% im Jahr 2023, jedoch einen deutlichen Anstieg der Nennung in kriminalisierenden Kontexten von 20,3% auf 39,9%. Behandlungsmöglichkeiten wurden insgesamt nur in 18,5% der Beiträge thematisiert.</jats:p> <jats:p>Trotz positiver Entwicklungen weist die Berichterstattung weiterhin stigmatisierende Tendenzen auf. Eine engere Kommunikation zwischen psychiatrischem Fachpersonal und Medienschaffenden erscheint als wichtiger Ansatzpunkt, um stigmatisierende Berichterstattung zu reduzieren.</jats:p>

Added

2026-09-12

Last modified

2026-09-12

Homepage URL

https://doi.org/10.3389/fpsyg.2026.1704951

Contributors

• Mitra Onsori
• Meredith Stone
• Imke Grimm
• Dorothea von Haebler

Citation (APA)

Onsori M, Stone M, Grimm I and
von Haebler D (2026) A psychotic
dilemma: psychodynamic group
therapy for patients with schizophrenia
in times of crisis.
Front. Psychol. 17:1704951.
doi: 10.3389/fpsyg.2026.1704951

Added

2026-02-26

Last modified

2026-02-26

Language

English

Homepage URL

http://dx.doi.org/10.1002/jclp.70052

Contributors

• Anna‐Lena Bröcker (Author, 0000-0001-9933-2213)
• Helen Sauter (Author)
• Dorothea von Haebler (Author)
• Christiane Montag (Author)
• Sandra Anna Just (Author)

Citation (APA)

Bröcker, A.-L., Sauter, H., von Haebler, D., Montag, C., & Just, S. A. (2025). Gender Differences in Social Cognition and Their Association With Functioning in Individuals With Non‐Affective Psychosis. Journal of clinical psychology. https://doi.org/10.1002/jclp.70052

Description

<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>Previous studies in non‐affective psychosis (NAP) consistently found that patients' functioning is associated with social cognition and gender, with higher functioning in female patients. This study investigated the impact of social cognition on the relationship between gender and functioning, and examined psychometric properties of the Narrative Emotions Task (NET) as a measure of social cognition with high ecological validity.</jats:p></jats:sec><jats:sec><jats:title>Design and Methods</jats:title><jats:p><jats:italic>N</jats:italic> = 95 outpatients with NAP were assessed regarding functioning, social cognition, and psychopathology. Correlations were computed and a potential indirect effect of gender on functioning, mediated by social cognition, was examined.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Results showed a significant positive correlation between social cognition and functioning, with female patients exhibiting higher functioning. There were no gender differences in the total score of the NET, and the indirect effect of social cognition through gender on functioning could not be confirmed. Gender differences in social cognition were only evident for the NET emotion perception index. Moreover, there was some evidence of a potentially mediating effect of emotion perception concerning the relationship between gender and functioning, but this effect was not significant when covariates were added to the analysis. The NET showed high internal consistency and was correlated with an established instrument of metacognition (Metacognition Assessment Scale‐Abbreviated).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The findings equally broaden the picture and highlight the need for further investigation into gender differences in NAP, their underlying mechanisms, and their impact on functioning. The NET appears to be a feasible measure for assessing social cognition, going beyond laboratory tasks.</jats:p></jats:sec>

Added

2025-10-15

Last modified

2025-10-15

Language

German

Homepage URL

http://dx.doi.org/10.13109/zptm.2025.71.3.225

Contributors

• Valentin Lackmann (Author)
• Miriam Henkel (Author)
• Cord Benecke (Author)
• Claudia Kozik (Author)
• Knut Schnell (Author)
• Christian Fricke-Neef (Author)
• Bettina Mardus (Author)
• Martin Ohlmeier (Author)
• Dorothea von Haebler (Author)
• Christian Sell (Author)

Added

2025-09-06

Last modified

2025-09-06

Homepage URL

http://dx.doi.org/10.3389/fpsyt.2024.1388478

Contributors

• Samuel Bayer (Author)
• Anna-Lena Bröcker (Author)
• Frauke Stuke (Author)
• Sandra Just (Author)
• Gianna Bertram (Author)
• Imke Grimm (Author)
• Eva Maaßen (Author)
• Marielle Büttner (Author)
• Andreas Heinz (Author)
• Felix Bermpohl (Author)
• Günter Lempa (Author)
• Dorothea von Haebler (Author)
• Christiane Montag (Author)

Description

The psychic structure of people with psychosis has been the subject of theoretical and qualitative considerations. However, it has not been sufficiently studied quantitatively. Therefore, the aim of this study was to explore the structural abilities of people diagnosed with schizophrenia and schizoaffective psychosis using the Levels of Structural Integration Axis of the Operationalized Psychodynamic Diagnosis System (OPD-2-LSIA). The study aimed to determine possible associations between the OPD-2-LSIA and central parameters of illness. Additionally, possible structural differences between people diagnosed with schizophrenia and schizoaffective psychosis were tested.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This cross-sectional study included 129 outpatients with schizophrenia or schizoaffective disorders. Measures of structural integration, symptom load, severity of illness, cognition, and social functioning were obtained. Descriptive statistics were used to analyze the overall structural level and the structural dimensions. Correlation coefficients were computed to measure the associations between OPD-2-LSIA and variables regarding the severity of illness and psychosocial functioning. Regression models were used to measure the influence of illness-related variables on OPD-2-LSIA, and the influence of OPD-2-LSIA on psychosocial functioning. Participants diagnosed with schizophrenia and schizoaffective disorders were examined with regard to possible group differences.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The results of the OPD-2-LSIA showed that the overall structural level was between ‘moderate to low’ and ‘low level of structural integration’. Significant correlations were found between OPD-2-LSIA and psychotic symptoms (but not depressive symptoms), as well as between OPD-2-LSIA and psychosocial functioning. It was found that variables related to severity of illness had a significant impact on OPD-2-LSIA, with psychotic, but not depressive symptoms being significant predictors. OPD-2-LSIA was found to predict psychosocial functioning beyond symptoms and cognition. No significant differences were found between participants with schizophrenia and schizoaffective psychosis. There was also no correlation found between OPD-2-LSIA and depressive symptomatology (except for the subdimension Internal communication).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Contrary to theoretical assumptions, the results of the study show a heterogenous picture of the psychic structure of people with psychosis. The associations between OPD-2-LSIA and severity of illness, particularly psychotic symptomatology, as well as the influence of OPD-2-LSIA on psychosocial functioning, are discussed.</jats:p></jats:sec>

Added

2025-05-27

Last modified

2025-05-27

Language

German

Homepage URL

http://dx.doi.org/10.1055/a-2293-4982

Contributors

• Dorothea von Haebler (Author)
• Thomas Bock (Author)

Added

2025-05-27

Last modified

2025-05-27

Homepage URL

https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1229113/pdf

Contributors

• Bröcker AL (Author)
• von Haebler D (Author, 0000-0001-6652-4331)
• Lempa G (Author)
• Montag C (Author)

Citation (unspecified style)

FactScience

Added

2023-07-25

Last modified

2023-07-25

Contributors

• Bröcker AL (Author, 0000-0001-9933-2213)
• Zimmermann J (Author, 0000-0001-6975-2356)
• Stuke F (Author)
• Just S (Author, 0000-0001-8833-1805)
• Bayer S (Author)
• Mielau J (Author)
• Bertram G (Author)
• Funcke J (Author)
• Maaßen E (Author)
• Hadzibegovic J (Author)
• Lempa G (Author)
• von Haebler D (Author, 0000-0001-6652-4331)
• Montag C (Author, 0000-0002-3307-276X)

Citation (unspecified style)

FactScience

Description

Synthetic metacognition is a heterogeneous construct related to psychotic disorders. One important tool to assess this construct is the Metacognition Assessment Scale - Abbreviated (MAS-A). In this study, we investigated the latent structure as well as the interrater reliability and convergent and incremental validity of the MAS-A in a sample of patients with non-affective psychosis. Analyses indicated that the scale might be one-dimensional. Interrater reliability of the MAS-A total score was good. In terms of convergent validity, correlational analyses showed significant associations of MAS-A metacognition with the Operationalized Psychodynamic Diagnosis Level of Structural Integration Axis (OPD-LSIA) and the Levels of Emotional Awareness Scale (LEAS). In terms of construct validity, a significant association was observed between MAS-A metacognition and a short version of the International Classification of Functioning, Disability and Health (MINI-ICF), which persisted after self-report measures of impairments in structural capacities (Structure Questionnaire of Operationalized Psychodynamic Diagnosis [OPD-SQS]) and mentalizing abilities (Mentalization Questionnaire [MZQ]) were included as covariates, but not after symptom dimensions were included. There was a significant correlation with the current living situation, but not with other external criteria like diagnosis or duration of illness. Future studies should explore alternative outcomes and replicate results in longitudinal designs.

Added

2022-06-28

Last modified

2022-06-28

Homepage URL

https://www.vandenhoeck-ruprecht-verlage.com/psychodynamik

Contributors

• Von Haebler D (Author)
• Montag C (Author, 0000-0001-6652-4331)
• Lempa G (Author)

Citation (unspecified style)

FactScience

Added

2022-03-29

Last modified

2022-06-03

Homepage URL

https://www.klett-cotta.de/produkt/365-x-freud-9783608984446-t-5089

Contributors

• Dorothea von Haebler (0000-0001-6652-4331)

Citation (APA)

Psychosenpsychotherapie
D. von Haebler
In: 365 x Freud. Ein Lesebuch für jeden Tag, edited by T. Nolte and K. Rugenstein
Klett-Cotta Verlag 2022 1. edn.

Added

2025-05-27

Last modified

2025-05-27

Contributors

• von Haebler D (Author, 0000-0001-6652-4331)
• Brinkmann K (Author)

Citation (unspecified style)

FactScience

Added

2023-07-25

Last modified

2023-07-25

Homepage URL

https://elibrary.klett-cotta.de/article/10.21706/ptt-25-2-123

Contributors

• von Haebler D (Author, 0000-0001-6652-4331)
• Grimm I (Author)

Citation (unspecified style)

FactScience

Added

2022-03-29

Last modified

2022-06-03

Contributors

• Haebler, von D (Author, 0000-0001-6652-4331)

Citation (unspecified style)

FactScience

Added

2023-07-25

Last modified

2023-07-25

Homepage URL

https://www.frontiersin.org/articles/10.3389/fpsyg.2021.725787/pdf

Contributors

• Maaßen E (Author)
• Büttner M (Author)
• Bröcker AL (Author)
• Stuke F (Author)
• Bayer S (Author)
• Hadzibegovic J (Author)
• Just SA (Author)
• Bertram G (Author)
• Rau R (Author)
• von Haebler D (Author)
• Lempa G (Author)
• Montag C (Author)

Citation (unspecified style)

FactScience

Description

The ability to mentalize (i.e., to form representations of mental states and processes of oneself and others) is often impaired in people with schizophrenia spectrum disorders. Emotional awareness (EA) represents one aspect of affective mentalizing and can be assessed with the Levels of Emotional Awareness Scale (LEAS), but findings regarding individuals with schizophrenia spectrum disorders are inconsistent. The present study aimed at examining the usability and convergent validity of the LEAS in a sample of N = 130 stabilized outpatients with schizophrenia or schizoaffective disorders. An adequacy rating was added to the conventional LEAS rating to account for distortions of content due to, for example, delusional thinking. Scores of the patient group were compared with those of a matched healthy control sample. Correlation with symptom clusters, a self-report measure of EA, a measure of synthetic metacognition (MAS-A-G), and an expert rating capturing EA from the psychodynamic perspective of psychic structure (OPD-LSIA) were examined. Regarding self-related emotional awareness, patients did not score lower than controls neither in terms of conventional LEAS nor in terms of adequacy. Regarding other-related emotional awareness, however, patients showed a reduced level of adequacy compared to controls whereas no such difference was found for conventional LEAS scores. Higher conventional LEAS scores were associated with fewer negative symptoms, and higher structural integration of self-perceptions measured by the OPD-LSIA. Higher adequacy of responses correlated with fewer symptoms of disorganization as well as excitement, higher scores of self-reflection on the MAS-A-G as well as self- and object-perception and internal and external communication as measured by the subscales of the OPD-LSIA. Findings suggest that the LEAS might not be sensitive enough to detect differences between mildly symptomatic patients with schizophrenia or schizoaffective disorders and healthy controls. However, LEAS ratings are still suitable to track intraindividual changes in EA over time. Observing the adequacy of patients' responses when using the LEAS may be a promising way to increase diagnostical utility and to identify patterns of formal and content-related alterations of mentalizing in this patient group. Methodological indications for future studies are discussed.

Added

2022-03-27

Last modified

2022-06-03

Language

German

Subtitle

Innovativer Aufbruch oder einseitiger Rückschritt?

Homepage URL

http://dx.doi.org/10.1055/a-1321-1826

Contributors

• Thomas Bock (Author)
• Roswitha Hurtz (Author)
• Stefan Klingberg (Author)
• Andreas Bechdolf (Author)
• Dorothea von Haebler (Author)

Added

2025-05-27

Last modified

2025-05-27

Homepage URL

https://link.springer.com/content/pdf/10.1007/s00451-020-00390-w.pdf

Contributors

• Sell C (Author)
• Henkel M (Author)
• Grant P (Author)
• von Haebler D (Author, 0000-0001-6652-4331)
• Dümpelmann M (Author)
• Ohlmeier M (Author)
• Schnell K (Author)
• Spitzer C (Author)
• Mardus B (Author)
• Benecke C (Author)

Citation (unspecified style)

FactScience

Added

2022-03-29

Last modified

2022-06-03

Homepage URL

https://www.kerbe.info/inhalt/kerbe-forum-fuer-soziale-psychiatrie-heft-1-2020/

Contributors

• Dorothea von Haebler (0000-0001-6652-4331)
• Klaus Hesse

Citation (APA)

Gruppenpsychotherapieangebote für Menschen mit Psychosen
D. von Haebler and K. Hesse
Kerbe - Forum für soziale Psychiatrie 2020 Vol. 38 Issue 1 Pages 22-24

Added

2025-05-27

Last modified

2025-05-27

Homepage URL

https://doi.org/10.3389/fpsyg.2020.00269

Contributors

• Bröcker AL (Author)
• Bayer S (Author)
• Stuke F (Author)
• Just S (Author)
• Bertram G (Author)
• Funcke J (Author)
• Grimm I (Author)
• Lempa G (Author)
• von Haebler D (Author)
• Montag C (Author)

Citation (unspecified style)

FactScience

Description

Synthetic metacognition is defined by integrative and contextualizing processes of discrete reflexive moments. These processes are supposed to be needed to meet intrapsychic as well as interpersonal challenges and to meaningfully include psychotic experience in a personal life narrative. A substantial body of evidence has linked this phenomenon to psychosocial functioning and treatment options were developed. The concept of synthetic metacognition, measured with the Metacognition Assessment Scale-Abbreviated (MAS-A), rises hope to bridge gaps between therapeutic orientations and shares valuable parallels to modern psychodynamic constructs, especially the 'levels of structural integration' of the Operationalized Psychodynamic Diagnosis (OPD-2). As theoretical distinctions remain, aim of this study was to compare the predictive value of both constructs with regard to psychosocial functioning of patients with non-affective psychoses, measured with the International Classification of Functioning, Disability and Health (MINI-ICF-APP). It was further explored if levels of structural integration (OPD-LSIA) would mediate the impact of metacognition (MAS-A) on function (MINI-ICF-APP). Expert ratings of synthetic metacognition (MAS-A), the OPD-2 'levels of structural integration' axis (OPD-LSIA), psychosocial functioning (MINI-ICF-APP) and assessments of general cognition and symptoms were applied to 100 individuals with non-affective psychoses. Whereas both, MAS-A and OPD-LSIA, significantly predicted MINI-ICF-APP beyond cognition and symptoms, OPD-LSIA explained a higher share of variance and mediated the impact of MAS-A on MINI-ICF-APP. Levels of structural integration, including the quality of internalized object representations and unconscious interpersonal schemas, might therefore be considered as valuable predictors of social functioning and as one therapeutic focus in patients with non-affective psychoses. Structural integration might go beyond and form the base of a person's actual reflexive and metacognitive capabilities. Psychotherapeutic procedures specific for psychoses may promote and challenge a patient's metacognitive capacities, but should equally take the need for maturing structural skills into account. Modern psychodynamic approaches to psychosis are shortly presented, providing concepts and techniques for the implicit regulation of interpersonal experience and aiming at structural integration in this patient group.

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Dorothea von Haebler (0000-0001-6652-4331)
• Günter Lempa

Citation (APA)

Psychodynamische Psychosentherapie und das schizophrene Dilemma
D. von Haebler and G. Lempa
VPP aktuell 2020 Vol. 49 Pages 4-6

Added

2025-05-27

Last modified

2025-05-27

Homepage URL

https://www.psychotherapeutenjournal.de/ptk/web.nsf/id/li_fdihbqmexc.html

Contributors

• Dorothea von Haebler (0000-0001-6652-4331)

Citation (APA)

Psychotherapeuten und ihre zentrale Rolle bei komplexem Behandlungsbedarf - für Menschen mit Psychosen
D. von Haebler
Psychotherapeutenjournal 2020 Vol. 2020 Issue 1 Pages 63-64

Added

2025-05-27

Last modified

2025-05-27

Homepage URL

https://doi.org/10.1002/cpp.2437

Contributors

• Frauke Stuke (Author)
• Anna‐Lena Bröcker (Author)
• Samuel Bayer (Author)
• Andreas Heinz (Author)
• Felix Bermpohl (Author)
• Günter Lempa (Author)
• Dorothea von Haebler (Author)
• Christiane Montag (Author)

Added

2020-10-26

Last modified

2023-09-03

Homepage URL

https://link.springer.com/article/10.1007/s11757-019-00521-y

Contributors

• von Haebler D (Author)
• Montag C (Author)

Citation (unspecified style)

FactScience

Added

2021-04-28

Last modified

2022-06-01

Homepage URL

https://www.kup.at/kup/pdf/14161.pdf

Contributors

• Dorothea von Haebler (0000-0001-6652-4331)

Citation (APA)

Therapeutische Haltung als Zugang zur Psychotherapie für Menschen mit schizophrenen Psychosen und die Notwendigkeit einer Modifikation der psychodynamischen Behandlungstechnik
D. von Haebler
Journal für Neurologie, Neurochirugie und Psychiatrie 2018 Vol. 19 Issue 1 Pages 28-32

Added

2025-05-27

Last modified

2025-05-27

Contributors

• Lempa G (Author)
• von Haebler D (Author)
• Montag C (Author)

Citation (unspecified style)

FactScience

Description

Psychotherapie stellt bei der Behandlung von Menschen mit Psychosen aus dem schizophrenen Formenkreis mittlerweile einen unverzichtbaren Bestandteil dar. Gleichwohl herrscht im Bereich der psychodynamischen Verfahren häufig noch Unklarheit über den gezielten Einsatz psychosespezifischer therapeutischer Interventionen. Die AutorInnen legen erstmals ein Manual für eine modifizierte psychodynamische Psychotherapie vor: Unter Einbeziehung aktueller neurowissenschaftlicher Erkenntnisse stellen sie das psychosespezifische therapeutische Vorgehen dar, insbesondere in Bezug auf den therapeutischen Rahmen, die Beziehungsgestaltung sowie die phasengerechte therapeutische Intervention. Ihre Ausführungen illustrieren sie anhand zahlreicher Fallbeispiele. Das Buch richtet sich insbesondere an ärztliche und psychologische PsychotherapeutInnen sowie im psychiatrischen und komplementären Bereich tätige ÄrztInnen und PsychologInnen.

Added

2021-04-28

Last modified

2022-06-01

Homepage URL

https://psychiatrie-verlag.de/product/psu-1-2016-komplett/

Contributors

• Dorothea von Haebler (0000-0001-6652-4331)
• Merle Becker

Citation (APA)

Psychotherapie für Menschen mit Psychosen - Aus- und Fortbildungsangebote sind gefragt
D. von Haebler and M. Becker
Psychosoziale Umschau 2016 Vol. 31 Issue 1 Pages 8-9

Added

2025-05-27

Last modified

2025-05-27

Contributors

• von Haebler D (Author)

Citation (unspecified style)

FactScience

Added

2021-04-28

Last modified

2022-06-01

Contributors

• von Haebler D (Author)

Citation (unspecified style)

FactScience

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Lempa G (Author)
• Montag C (Author)
• von Haebler D (Author)

Citation (unspecified style)

FactScience

Added

2021-04-28

Last modified

2022-06-01

Homepage URL

https://link.springer.com/article/10.1007/s00278-013-0994-4

Contributors

• von Haebler D (Author)
• Freyberger H (Author)

Citation (unspecified style)

FactScience

Added

2021-05-18

Last modified

2022-06-01

Contributors

• Uzdawinis D (Author)
• Edel MA (Author)
• Ozgürdal S (Author)
• von Haebler D (Author)
• Hauser M (Author)
• Witthaus H (Author)
• Gudlowski Y (Author)
• Heinz A (Author)
• Juckel G (Author)

Citation (unspecified style)

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Description

To obtain data and hypotheses regarding the amelioration of risk estimation and preventive psychotherapy in patients in a prodromal state of schizophrenia by using OPD.

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Manahan-Vaughan D (Author)
• von Haebler D (Author)
• Winter C (Author)
• Juckel G (Author)
• Heinemann U (Author)

Citation (unspecified style)

FactScience

Description

Schizophrenia is mostly a progressive psychiatric illness. Although cognitive changes in chronic schizophrenia have been investigated, little is known about the consequences of a single psychotic episode on memory mechanisms and formation. We investigated changes in hippocampal long-term potentiation (LTP) and spatial memory in a rat model of an acute psychotic episode. Application of NMDA receptor antagonists, such as MK801 (dizolcilpine) in rats, have been shown to give rise to an acute and short-lasting behavioral state, which mirrors many symptoms of schizophrenia. Furthermore, NMDA antagonist-intake in humans elicits symptoms of schizophrenia such as hallucinations, delusions, and affective blunting. We therefore treated animals with a single systemic injection of MK801 (5 mg/kg). Increased stereotypy, locomotion, and ataxia were evident immediately after MK801-treatment, with effects disappearing within 24 h. MK801-treatment caused a disruption of prepulse inhibition of the acoustic startle reflex, 1 day but not 7 or 28 days after treatment. These effects were consistent with the occurrence of an acute psychotic episode. LTP was profoundly impaired in freely moving rats 7 days after MK801 application. Four weeks after treatment, a slight recovery of LTP was seen, however marked deficits in long-term spatial memory were evident. These data suggest that treatment with MK801 to generate an acute psychotic episode in rats, gives rise to grave disturbances in synaptic plasticity and is associated with lasting impairments with the ability to form spatial memory.

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2021-04-28

Last modified

2022-06-01

Contributors

• Gallinat J (Author)
• Lang UE (Author)
• Jacobsen LK (Author)
• Bajbouj M (Author)
• Kalus P (Author)
• von Haebler D (Author)
• Seifert F (Author)
• Schubert F (Author)

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FactScience

Description

In animals, nicotine, the primary psychoactive constituent of tobacco smoke, reduces neurogenesis and increases cell loss in both hippocampus and cortex. Accordingly, tobacco smoking has been linked to reduced performance on cognitive paradigms requiring attention and working memory in humans. However, few prior studies have tested for evidence of structural brain alterations in human tobacco smokers. In this study, proton magnetic resonance spectroscopy was used to assess the effects of chronic smoking on neuronal integrity of the hippocampus and anterior cingulate cortex (ACC).

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2021-04-28

Last modified

2022-06-01

Contributors

• Wöhrl R (Author)
• Eisenach S (Author)
• Manahan-Vaughan D (Author)
• Heinemann U (Author)
• von Haebler D (Author)

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FactScience

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We analysed acute and long-term effects of the N-methyl-d-aspartate receptor antagonist MK-801 on long-term heterosynaptic population spike depression (LTHPSD) evoked by high-frequency stimulation of the direct cortical input in female rat hippocampal slices to understand disturbances in cognitive functions associated with an acute phencyclidine-induced psychosis. High-frequency stimulation (HFS) of the direct cortical input (dCI) to cornu ammonis area 1 (CA1) induced homosynaptic long-term potentiation (LTP) while simultaneously evoking LTHPSD at the Schaffer collateral input. Animals treated with a single intraperitoneal application of MK-801 (5 mg/kg body weight) showed severe behavioural alterations for 24 h, although histological examination of CA1 did not reveal any morphological changes. However, after application of MK-801, homosynaptic LTP of the dCI was suppressed for up to 7 days and recovered within 4 weeks. Likewise, LTHPSD in response to HFS of the dCI to CA1 was abolished for at least 1 week post-treatment, with partial recovery occurring after 4 weeks. Homosynaptic LTP, induced by HFS of Schaffer collaterals, was also disturbed for at least 24 h, with recovery after 7 days. Remarkably, bath application of MK-801 (50 microM) converted LTHPSD, induced by dCI HFS, into persistent heterosynaptic long-term enhancement of stratum radiatum-evoked responses. The acute effects of MK-801 on synaptic plasticity seen in this study may contribute to the observed severe behavioural alterations and long-term effects and may explain some of the long-lasting symptoms remaining after an acute psychotic episode in humans.

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Wöhrl R (Author)
• von Haebler D (Author)
• Heinemann U (Author)

Citation (unspecified style)

FactScience

Description

The entorhinal cortex (EC) innervates area CA1 and the subiculum directly via the portion of the perforant path, which originates from EC layer III cells referred to as direct cortical input (dCI), and indirectly via the trisynaptic loop through the dentate gyrus and area CA3. The dCI is of great importance as it mediates positional information for activation of place cells that is not prevented after interrupting information flow from area CA3 to CA1. In this study, we investigated the effects of low-frequency stimulation of the dCI on homo- and heterosynaptic plasticity in area CA1 and tested for the contribution of NMDA, GABA(A), GABA(B), kainate and group I mGlu receptors. We demonstrate that 1 Hz stimulation of the dCI induces homosynaptic long-term depression (LTD) and that 1 Hz stimulation of the dCI induces a long-lasting augmentation of stratum radiatum-induced population spikes in area CA1 (heterosynaptic long-term potentiation). Additionally we show that homosynaptic effects depend on activation of GABA(B) and kainate receptors, whereas the heterosynaptic effects are GABA(A) and mGlu receptor dependent.

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Neuhaus A (Author)
• Bajbouj M (Author)
• Kienast T (Author)
• Kalus P (Author)
• von Haebler D (Author)
• Winterer G (Author)
• Gallinat J (Author)

Citation (unspecified style)

FactScience

Description

Chronic smoking and nicotine exposure are accompanied by impaired cognitive task performance, modulated cerebral activity in brain imaging studies, and neuritic damage in experimental animals. The profile of the described dysfunctions matches frontal lobe circuits which also play a role in reward processing and reinforcement behavior. However, it is largely unknown if cerebral dysfunctions are reversible or persist during long term abstinence.

Added

2021-04-28

Last modified

2022-06-01

Contributors

• von Haebler D (Author)
• Stabel J (Author)
• Draguhn A (Author)
• Heinemann U (Author)

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FactScience

Description

In an ontogenetic study, combining morphological analysis and patch clamp recordings, a transiently appearing horizontal cell type was identified in the dentate gyrus. The cells were exclusively located in the outer third of the stratum moleculare. They were present at postnatal day 2 (P2) and could be identified with fluorescent dyes until around P14. The morphology was bipolar, with a putative axonal and a dendritic process stretching out parallel to the pial surface without any preferential direction. Patch clamp studies in the current and voltage clamp mode were performed in hippocampal slices on visually identified horizontal cells, between P4 and P7, which were subsequently stained with lucifer yellow. The cells had a low resting membrane potential, around -55 mV. They were excitable, displaying broad action potentials (duration 3-20 ms) and, unlike mature dentate granule cells, they also expressed a strong delayed inward rectifier with properties reminiscent of the IQ current. Unlike granule cells, no postsynaptic signals could be observed during elevation of [K+]o or electrical stimulation, suggesting that the horizontal cells did not participate in functional hippocampal circuitry. We suggest that these cells represent migrating cells with subsequent differentiation to granule cells or inhibitory interneurons. Alternatively they may be part of the early radial glia or serve as transient target cells for afferent fibres between the entorhinal cortex and the dentate gyrus.

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Heinemann U (Author)
• Albrecht D (Author)
• Beck H (Author)
• Ficker E (Author)
• von Haebler D (Author)
• Stabel J (Author)

Citation (unspecified style)

FactScience

Added

2021-04-28

Last modified

2022-06-01

Contributors

• Boulton CL (Author)
• von Haebler D (Author)
• Heinemann U (Author)

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FactScience

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In order to demonstrate axonal connections preserved in rat temporal cortex slices the authors used rhodamine-dextran-amine as a tracer. The slices contained the neocortical areas Te2 and Te3, the medial and lateral entorhinal cortices (MEC and LEC), the subicular regions, and the dentate gyrus and hippocampus proper. Rhodamine-dextran-amine crystals were placed by microinjection into a given area. Following this local lesioning the dye was permitted to diffuse and migrate intraaxonally in antero- and retrograde directions for about 8 hours. The slices were then formaldehyde-fixed and analyzed by fluorescence microscopy. Most of the known connections within and between the entorhinal cortex and the hippocampus and dentate gyrus were preserved in the slice preparation, provided that the slices were cut with a near horizontal orientation corresponding to plates 99-108 in Paxinos and Watson (1986). Only the lateral perforant path between the LEC and the hippocampus could not be followed to its full extent. The authors conclude that most aspects of the intrinsic synaptic organization of the temporal lobe can be reliably studied in hippocampal-entorhinal cortex slice preparations.

Added

2021-04-28

Last modified

2022-06-01