In a two-branched, prospective, single-blind and randomised-controlled efficacy study, 120 patients diagnosed with schizophrenia or a schizoaffective psychosis are being studied. Half of the test persons has been allocated to a patient group who are receiving 30 individual psychodynamic psychotherapy sessions over the course of one year. A newly developed manual on psychodynamic psychotherapy is being applied here. The study therapists receive detailed instructions in this manual and regular supervision during their treatment work. The second half of the test persons has been allocated to a control group (TAU) and is continuing to retain the psychiatric treatment to date (without any psychotherapy guidelines).
In addition, both groups are receiving extensive diagnostics, consisting of four study visits. The study visits include a range of questionnaires, as well as interviews on the psychosocial functioning level and on the symptom severity, as well as on the structure, mentalisation and metacognition. They are being conducted by examiners trained in psychiatric psychotherapy. The audio recordings of the study visits and the study therapies are being evaluated by a collective body of assessors.
The aim of the study is to assess the effectiveness and soundness of psychodynamic psychosis psychotherapy on the basis of a randomised-controlled study design. The study is examining the effects of psychodynamic psychotherapy on the psychosocial functioning level of the patients (primary study aim), the effects on the specific symptoms, on the need to have hospital treatment, on the "psychic structure", the metacognitive functions and the mentalisation ability parameters, as well as the effects on the ability to solve interpersonal problems.
In an explorative part of the study, the test persons are undergoing an fMRT examination. The intention is this regard is to assess psychodynamic hypotheses in the treatment of psychoses over the course of the study.
Specific participation conditions were set in order to be permitted to participate in the study. The following have been defined as the inclusion and exclusion criteria:
The MPP-S Study aims to examine the effectiveness and soundness of psychodynamic psychosis psychotherapy. As no systematic study has been conducted here to date, which fulfils the prevailing scientific criteria, the MPP-S Study is capable of making a fundamental contribution to psychodynamic psychotherapy research.