MODE - Modification of Psychological and Neural Structures in Long-Term Psychoanalytic Therapies for Depression

Since 2019 (ongoing)

Funded by the International Psychoanalytic Association (IPA) and the American Psychoanalytic Association (APsaA)

Research team

  • Prof. Tamara Fischmann (IPU)
  • Prof. Marianne Leuzinger-Bohleber (Uni Mainz)
  • Prof. Nikolai Axmacher (Uni Bochum)
  • Dr. Gilles Ambresin (CHUV Luasanne)
  • Prof. Brad Peterson (CHLA Los Angeles, USA)

Project description

MODE investigates the outcomes of high-frequency and low-frequency psychoanalysis in early traumatized, chronically depressed patients. Patients will be randomly assigned to one of two treatment conditions. A treatment manual will be available for the study therapists. Outcomes of the treatments will be examined in terms of symptom reduction (using standard psychological measures), structural change (defined by psychoanalytic methods), and neurobiological change (assessed by fMRI). 

Centers of the study are Frankfurt, Cologne/Bochum, Leipzig/Berlin, Lausanne, and Los Angeles. The study is supported by the International Psychoanalytical Association (IPA) and the American Psychoanalytic Association (APsaA). The research team is trying to raise additional funds (application to the Swiss National Science Foundation/German Research Foundation).