Effectiveness of Long-term Therapies of Chronically Depressive Patients

2011 / Project Head: Dr. Wolfram Keller

Project Description
Psychoanalytical and cognitive-behavioural therapeutic longterm therapies with chronic depression. Short-term and longterm effects with preferenced and randomised therapy assignments: The "LAC" study.

Wolfram Keller (IPU Berlin)
In cooperation with:
Marianne Leuzinger-Bohleber, Ulrich Bahrke, Lisa Kallenbach (Sigmund Freud Institute Frankfurt)
Martin Hautzinger (University Tübingen), Manfred Beutel (University Mainz), G. Fiedler (University Hamburg-Eppendorf), B. Rüger (University Munich, LMU) among others.

The LAC depression study has been supported since 2007, following preparatory work conducted over several years, by the German Society for Psychoanalysis, Psychotherapy and Psychosomatics (DGPT) the Heidehofstiftung foundation, the International Psychoanalytic Association (IPA), the German Research Foundation (DFG), Dr. von der Tann, the Research Advisory Board of the IPA and further private sponsors. In the meantime, more than 400 chronically depressive patients have been recruited. As it proved possible to already complete the preference arm two years ago and the recruitment since then has concentrated on filling the randomisation arm, the first findings from the preferenced psychoanalytical and behavioural therapeutic treatments are being investigated by the independent Methodenzentrum methods centre in Munich.

The aim of the LAC study is the controlled comparison of two proven psychotherapies which have established themselves in the field of care (psychoanalytical therapy, cognitive behavioural therapy) for the treatment of chronic depressions. The design allows for a preference arm and a randomisation arm. In both arms, the treatment is provided by certified, established and experienced specialists in their specific therapy, who are being supervised in the context of the LAC study. All of the therapy sessions are being recorded in order to assess the adherence.